There Is No “Stem Cell Mess”

There is no lexicon!

0. Introduction Within generative linguistics, underlying representations have been a sine qua non. Such representations have been thought to encode what is unpredictable or not governed by rules. Within Optimality Theory (henceforth OT), even though the rules are virtually gone, this view continues. The function GEN and EVAL pair an underlying representation with an optimal output. I argue aga...

There is no Parkinson disease.

The term Parkinson disease defines a specific clinical condition characterized by a typical history and characteristic signs. This review examines the historical evolution of the concept of Parkinson disease and how the misunderstanding of Parkinson disease may be hindering clinical research trials. It is proposed that this syndrome be called Parkinson diseases or parkinsonism type 1 through in...

There Is No Dividing Line

Where there is no overlap, there is a gap.

Cancer cell metabolism: there is no ROS for the weary.

Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and canc...